Mitochondrial ferritin is a nuclear encoded iron-storage protein localized in mitochondria. It has anti-oxidant properties related to its ferroxidase activity, and it is able to sequester iron avidly into the organelle. The protein has a tissue-specific pattern of expression and is also highly expressed in sideroblasts of patients affected by hereditary sideroblastic anemia and by refractory anemia with ringed sideroblasts. The present study examined whether mitochondrial ferritin has a role in the pathogenesis of these diseases.

Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation

Della Porta, Matteo Giovanni;
2011-01-01

Abstract

Mitochondrial ferritin is a nuclear encoded iron-storage protein localized in mitochondria. It has anti-oxidant properties related to its ferroxidase activity, and it is able to sequester iron avidly into the organelle. The protein has a tissue-specific pattern of expression and is also highly expressed in sideroblasts of patients affected by hereditary sideroblastic anemia and by refractory anemia with ringed sideroblasts. The present study examined whether mitochondrial ferritin has a role in the pathogenesis of these diseases.
2011
Animals
Apoptosis
Cell Line, Tumor
Ferritins
Gene Expression
Hematopoietic Stem Cells
Heme
Humans
Iron
Janus Kinase 2
K562 Cells
Mice
Mitochondria
Phosphorylation
Reactive Oxygen Species
STAT5 Transcription Factor
Transcription, Genetic
Signal Transduction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/70710
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