Triple-negative breast cancer (TNBC) is considered the most aggressive breast cancer subtype with the least favorable outcomes. However, recent research efforts have generated an enhanced knowledge of the biology of the disease and have provided a new, more comprehensive understanding of the multifaceted ecosystem that underpins TNBC.

Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets

Zambelli, Alberto;De Sanctis, Rita;Santoro, Armando;
2022-01-01

Abstract

Triple-negative breast cancer (TNBC) is considered the most aggressive breast cancer subtype with the least favorable outcomes. However, recent research efforts have generated an enhanced knowledge of the biology of the disease and have provided a new, more comprehensive understanding of the multifaceted ecosystem that underpins TNBC.
ADC
BRCAness
MAPK
PI3K-AKT-mTOR
TNBC subtypes
TROP-2
androgen receptor
epigenetics
immunotherapy
tumor heterogeneity
Ecosystem
Humans
Tumor Microenvironment
Triple Negative Breast Neoplasms
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/70729
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