The radio- and chemo-resistance of glioblastoma stem-like cells (GSCs), together with their innate tumor-initiating aptitude, make this cell population a crucial target for effective therapies. However, targeting GSCs is hardly difficult and complex, due to the presence of the blood-brain barrier (BBB) and the infiltrative nature of GSCs arousing their dispersion within the brain parenchyma.

Radiation and adjuvant drug-loaded liposomes target glioblastoma stem cells and trigger in-situ immune response

Matteoli, Michela;
2021-01-01

Abstract

The radio- and chemo-resistance of glioblastoma stem-like cells (GSCs), together with their innate tumor-initiating aptitude, make this cell population a crucial target for effective therapies. However, targeting GSCs is hardly difficult and complex, due to the presence of the blood-brain barrier (BBB) and the infiltrative nature of GSCs arousing their dispersion within the brain parenchyma.
blood–brain barrier
drug-loaded liposomes
glioblastoma stem cell
immunogenic cell death
radiotherapy
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/70774
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