Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

Chromogranin A levels and mortality in patients with severe sepsis

S. Aliberti;
2015-01-01

Abstract

Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
2015
Biological marker
cardiovascular diseases
Chromogranin A
mortality
sepsis
Aged
Biomarkers
Chromogranin A
Cohort Studies
Female
Hospital Mortality
Humans
Intensive Care Units
Male
Middle Aged
Multiple Organ Failure
Prognosis
Sepsis
Survival Analysis
Biochemistry
Clinical Biochemistry
Health
Toxicology and Mutagenesis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/74388
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