Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of beta endorphin in cirrhotic rats confirming that central neuropeptides are affected by chronic liver failure.
|Titolo:||Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis|
|Data di pubblicazione:||1983|
|Appare nelle tipologie:||1.1 Articolo in rivista|