A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance to antitumor therapies. Nevertheless, how stromal components including blood and lymphatic endothelial cells, pericytes and fibroblasts, as well as hematopoietic cells, respond to low-oxygen tension in comparison with their normoxic counterparts has been a matter of investigation in the last few years only and, to date, this field of research remains poorly understood. In general, opposing phenotypes can arise from the same stromal component when embedded in different tumor microenvironments, and, vice versa, different stromal components can have opposite reaction to the same tumor microenvironment. In this article, we will discuss the emerging link between tumor stroma and hypoxia, and how this complexity is translated at the molecular level. © 2014 Macmillan Publishers Limited.

Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment

Mazzone M.
2014-01-01

Abstract

A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance to antitumor therapies. Nevertheless, how stromal components including blood and lymphatic endothelial cells, pericytes and fibroblasts, as well as hematopoietic cells, respond to low-oxygen tension in comparison with their normoxic counterparts has been a matter of investigation in the last few years only and, to date, this field of research remains poorly understood. In general, opposing phenotypes can arise from the same stromal component when embedded in different tumor microenvironments, and, vice versa, different stromal components can have opposite reaction to the same tumor microenvironment. In this article, we will discuss the emerging link between tumor stroma and hypoxia, and how this complexity is translated at the molecular level. © 2014 Macmillan Publishers Limited.
2014
Angiogenesis
CAF
Cancer progression
Hypoxia
TAM
Tumor stroma
Animals
Blood Platelets
Cell Line
Tumor
Dendritic Cells
Disease Progression
Endothelial Cells
Fibroblasts
Gene Expression Regulation
Neoplastic
Humans
Hypoxia
Lymphocytes
Macrophages
Mice
Neoplasms
Neovascularization
Pathologic
Neutrophils
Oxygen
Pericytes
Phenotype
Signal Transduction
Stromal Cells
Cell Hypoxia
Tumor Microenvironment
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/83067
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