Bruning et al. report that blocking fatty acid synthase (FASN) in endothelial cells (ECs) reduces angiogenesis by impairing EC proliferation. Mechanistically, FASN inhibition elevates the malonyl-CoA substrate pool, thereby increasing post-translational malonylation of mTOR and decreasing the pro-angiogenic mTORC1 activity.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

Mazzone M.;
2018-01-01

Abstract

Bruning et al. report that blocking fatty acid synthase (FASN) in endothelial cells (ECs) reduces angiogenesis by impairing EC proliferation. Mechanistically, FASN inhibition elevates the malonyl-CoA substrate pool, thereby increasing post-translational malonylation of mTOR and decreasing the pro-angiogenic mTORC1 activity.
2018
angiogenesis
endothelial cell
fatty acid synthase
lipids
malonyl-CoA
metabolism
mTOR
mTORC1
post-translational modifications
protein malonylation
Acetyl-CoA Carboxylase
Animals
Cell Line
Tumor
Cell Proliferation
Fatty Acid Synthase
Type I
Human Umbilical Vein Endothelial Cells
Humans
Malonyl Coenzyme A
Mechanistic Target of Rapamycin Complex 1
Mice
Mice
Inbred C57BL
Mice
Knockout
Orlistat
Protein Processing
Post-Translational
Retinal Neovascularization
TOR Serine-Threonine Kinases
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/83086
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