Goveia et al. use single-cell RNA sequencing to provide an inventory of tumor endothelial cell (TEC) phenotypes from human and mouse non-small cell lung cancer and validate them functionally. Specific TEC phenotypes are associated with prognosis and response to anti-angiogenic therapy.

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Mazzone M.;
2020-01-01

Abstract

Goveia et al. use single-cell RNA sequencing to provide an inventory of tumor endothelial cell (TEC) phenotypes from human and mouse non-small cell lung cancer and validate them functionally. Specific TEC phenotypes are associated with prognosis and response to anti-angiogenic therapy.
2020
angiogenesis
anti-angiogenic therapy
cancer
endothelial cells
endothelial heterogeneity
multi-omics
single-cell RNA sequencing
Angiogenesis Inhibitors
Animals
Basement Membrane
Carcinoma
Non-Small-Cell Lung
Cell Line
Tumor
Cell Movement
Cluster Analysis
Collagen
Endothelial Cells
Endothelium
Vascular
Female
Humans
Lung Neoplasms
Male
Mice
Phenotype
Single-Cell Analysis
Vascular Endothelial Growth Factor A
Gene Expression Profiling
Gene Expression Regulation
Neoplastic
Neovascularization
Pathologic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/83139
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