The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.

PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Gremese, Elisa;
2011-01-01

Abstract

The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.
2011
Polymorphism
Single Nucleotide
Adult
Aged
Arthritis
Rheumatoid
Case-Control Studies
Europe
Gene Frequency
Genetic Predisposition to Disease
Genotype
Geography
Greece
Humans
Italy
Middle Aged
Mutation Rate
Protein Tyrosine Phosphatase
Non-Receptor Type 22
Spain
Tunisia
Turkey
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/85569
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