To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1.

Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus

Gremese, Elisa;
2012-01-01

Abstract

To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1.
2012
Polymorphism
Genetic
Immunoglobulin Heavy Chains
Lupus Erythematosus
Systemic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/85584
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