Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment
2014-01-01 Casazza, A.; Di Conza, G.; Wenes, M.; Finisguerra, V.; Deschoemaeker, S.; Mazzone, M.
BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis
2021-01-01 Vara-Perez, M.; Rossi, M.; Van den Haute, C.; Maes, H.; Sassano, M. L.; Venkataramani, V.; Michalke, B.; Romano, E.; Rillaerts, K.; Garg, A. D.; Schepkens, C.; Bosisio, F. M.; Wouters, J.; Oliveira, A. I.; Vangheluwe, P.; Annaert, W.; Swinnen, J. V.; Colet, J. M.; van den Oord, J. J.; Fendt, S. -M.; Mazzone, M.; Agostinis, P.
Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice
2010-01-01 Casazza, Andrea; Finisguerra, V; Capparuccia, Lorena; Camperi, Andrea; Swiercz, Jm; Rizzolio, Sabrina; Rolny, C; Christensen, C; Bertotti, Andrea; Sarotto, I; Risio, M; Trusolino, Livio; Weitz, J; Schneider, M; Mazzone, M; Comoglio, Paolo; Tamagnone, Luca
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer
2022-01-01 Cappellesso, F.; Orban, M. -P.; Shirgaonkar, N.; Berardi, E.; Serneels, J.; Neveu, M. -A.; Di Molfetta, D.; Piccapane, F.; Caroppo, R.; Debellis, L.; Ostyn, T.; Joudiou, N.; Mignion, L.; Richiardone, E.; Jordan, B. F.; Gallez, B.; Corbet, C.; Roskams, T.; Dasgupta, R.; Tejpar, S.; Di Matteo, M.; Taverna, D.; Reshkin, S. J.; Topal, B.; Virga, F.; Mazzone, M.
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth
2019-01-01 Garcia-Caballero, M.; Zecchin, A.; Souffreau, J.; Truong, A. -C. K.; Teuwen, L. -A.; Vermaelen, W.; Martin-Perez, R.; de Zeeuw, P.; Bouche, A.; Vinckier, S.; Cornelissen, I.; Eelen, G.; Ghesquiere, B.; Mazzone, M.; Dewerchin, M.; Carmeliet, P.
N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages
2021-01-01 Menga, A.; Favia, M.; Spera, I.; Vegliante, M. C.; Gissi, R.; De Grassi, A.; Laera, L.; Campanella, A.; Gerbino, A.; Carra, G.; Canton, M.; Loizzi, V.; Pierri, C. L.; Cormio, G.; Mazzone, M.; Castegna, A.
Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness
2021-01-01 Jiang, X.; Hu, J.; Wu, Z.; Cafarello, S. T.; Di Matteo, M.; Shen, Y.; Dong, X.; Adler, H.; Mazzone, M.; Ruiz de Almodovar, C.; Wang, X.
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
2017-01-01 Hernandez-Fernaud, J. R.; Ruengeler, E.; Casazza, A.; Neilson, L. J.; Pulleine, E.; Santi, A.; Ismail, S.; Lilla, S.; Dhayade, S.; Macpherson, I. R.; Mcneish, I.; Ennis, D.; Ali, H.; Kugeratski, F. G.; Al Khamici, H.; Van Den Biggelaar, M.; Van Den Berghe, P. V. E.; Cloix, C.; Mcdonald, L.; Millan, D.; Hoyle, A.; Kuchnio, A.; Carmeliet, P.; Valenzuela, S. M.; Blyth, K.; Yin, H.; Mazzone, M.; Norman, J. C.; Zanivan, S.
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation
2013-01-01 Luca, R.; Averna, M.; Zalfa, F.; Vecchi, M.; Bianchi, F.; Fata, G. L.; Del Nonno, F.; Nardacci, R.; Bianchi, M.; Nuciforo, P.; Munck, S.; Parrella, P.; Moura, R.; Signori, E.; Alston, R.; Kuchnio, A.; Farace, M. G.; Fazio, V. M.; Piacentini, M.; De Strooper, B.; Achsel, T.; Neri, G.; Neven, P.; Evans, D. G.; Carmeliet, P.; Mazzone, M.; Bagni, C.
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
2009-01-01 Mazzone, M; Dettori, Daniela; Leite de Oliveira, R; Loges, S; Schmidt, T; Jonckx, B; Tian, Ym; Lanahan, Aa; Pollard, P; Ruiz de Almodovar, C; De Smet, F; Vinckier, S; Aragonés, J; Debackere, K; Luttun, A; Wyns, S; Jordan, B; Pisacane, A; Gallez, B; Lampugnani, Mg; Dejana, E; Simons, M; Ratcliffe, P; Maxwell, P; Carmeliet, P.
Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation
2021-01-01 Virga, F.; Cappellesso, F.; Stijlemans, B.; Henze, A. -T.; Trotta, R.; van Audenaerde, J.; Mirchandani, A. S.; Sanchez-Garcia, M. A.; Vandewalle, J.; Orso, F.; Riera-Domingo, C.; Griffa, A.; Ivan, C.; Smits, E.; Laoui, D.; Martelli, F.; Langouche, L.; van den Berghe, G.; Feron, O.; Ghesquiere, B.; Prenen, H.; Libert, C.; Walmsley, S. R.; Corbet, C.; van Ginderachter, J. A.; Ivan, M.; Taverna, D.; Mazzone, M.
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis
2018-01-01 Kalucka, J.; Bierhansl, L.; Conchinha, N. V.; Missiaen, R.; Elia, I.; Bruning, U.; Scheinok, S.; Treps, L.; Cantelmo, A. R.; Dubois, C.; de Zeeuw, P.; Goveia, J.; Zecchin, A.; Taverna, F.; Morales-Rodriguez, F.; Brajic, A.; Conradi, L. -C.; Schoors, S.; Harjes, U.; Vriens, K.; Pilz, G. -A.; Chen, R.; Cubbon, R.; Thienpont, B.; Cruys, B.; Wong, B. W.; Ghesquiere, B.; Dewerchin, M.; De Bock, K.; Sagaert, X.; Jessberger, S.; Jones, E. A. V.; Gallez, B.; Lambrechts, D.; Mazzone, M.; Eelen, G.; Li, X.; Fendt, S. -M.; Carmeliet, P.
Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity
2013-01-01 Casazza, Andrea; Laoui, Damya; Wenes, Mathias; Sabrina, Rizzolio; Bassani, Nicklas; Mambretti, Marco; Deschoemaeker, Sofie; Van ginderachter, J. o. . A.; Luca, Tamagnone; Mazzone, Massimiliano
MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis
2016-01-01 Stijlemans, B.; Brys, L.; Korf, H.; Bieniasz-Krzywiec, P.; Sparkes, A.; Vansintjan, L.; Leng, L.; Vanbekbergen, N.; Mazzone, M.; Caljon, G.; Van Den Abbeele, J.; Odongo, S.; De Trez, C.; Magez, S.; Van Ginderachter, J. A.; Beschin, A.; Bucala, R.; De Baetselier, P.
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism
2017-01-01 Thompson, A. A. R.; Dickinson, R. S.; Murphy, F.; Thomson, J. P.; Marriott, H. M.; Tavares, A.; Willson, J.; Williams, L.; Lewis, A.; Mirchandani, A.; Coelho, P. D. S.; Doherty, C.; Ryan, E.; Watts, E.; Morton, N. M.; Forbes, S.; Stimson, R. H.; Hameed, A. G.; Arnold, N.; Preston, J. A.; Lawrie, A.; Finisguerra, V.; Mazzone, M.; Sadiku, P.; Goveia, J.; Taverna, F.; Carmeliet, P.; Foster, S. J.; Chilvers, E. R.; Cowburn, A. S.; Dockrell, D. H.; Johnson, R. S.; Meehan, R. R.; Whyte, M. K. B.; Walmsley, S. R.
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population
2014-01-01 Laoui, D.; Van Overmeire, E.; Conza, G. D.; Aldeni, C.; Keirsse, J.; Morias, Y.; Movahedi, K.; Houbracken, I.; Schouppe, E.; Elkrim, Y.; Karroum, O.; Jordan, B.; Carmeliet, P.; Gysemans, C.; Debaetselier, P.; Mazzone, M.; Van Ginderachter, J. A.
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function
2021-01-01 Duquenne, M.; Folgueira, C.; Bourouh, C.; Millet, M.; Silva, A.; Clasadonte, J.; Imbernon, M.; Fernandois, D.; Martinez-Corral, I.; Kusumakshi, S.; Caron, E.; Rasika, S.; Deliglia, E.; Jouy, N.; Oishi, A.; Mazzone, M.; Trinquet, E.; Tavernier, J.; Kim, Y. -B.; Ory, S.; Jockers, R.; Schwaninger, M.; Boehm, U.; Nogueiras, R.; Annicotte, J. -S.; Gasman, S.; Dam, J.; Prevot, V.
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis
2012-01-01 Kiss, J.; Mollenhauer, M.; Walmsley, S. R.; Kirchberg, J.; Radhakrishnan, P.; Niemietz, T.; Dudda, J.; Steinert, G.; Whyte, M. K. B.; Carmeliet, P.; Mazzone, M.; Weitz, J.; Schneider, M.
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity
2012-01-01 Leite de Oliveira, R.; Deschoemaeker, S.; Henze, A. -T.; Debackere, K.; Finisguerra, V.; Takeda, Y.; Roncal, C.; Dettori, D.; Tack, E.; Jonsson, Y.; Veschini, L.; Peeters, A.; Anisimov, A.; Hofmann, M.; Alitalo, K.; Baes, M.; D'Hooge, J.; Carmeliet, P.; Mazzone, M.
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium
2017-01-01 Reid, S. E.; Kay, E. J.; Neilson, L. J.; Henze, A. -T.; Serneels, J.; Mcghee, E. J.; Dhayade, S.; Nixon, C.; Mackey, J. B. G.; Santi, A.; Swaminathan, K.; Athineos, D.; Papalazarou, V.; Patella, F.; Roman-Fernandez, A.; Elmaghloob, Y.; Hernandez-Fernaud, J. R.; Adams, R. H.; Ismail, S.; Bryant, D. M.; Salmeron-Sanchez, M.; Machesky, L. M.; Carlin, L. M.; Blyth, K.; Mazzone, M.; Zanivan, S.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment | 1-gen-2014 | Casazza, A.; Di Conza, G.; Wenes, M.; Finisguerra, V.; Deschoemaeker, S.; Mazzone, M. | |
| BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis | 1-gen-2021 | Vara-Perez, M.; Rossi, M.; Van den Haute, C.; Maes, H.; Sassano, M. L.; Venkataramani, V.; Michalke, B.; Romano, E.; Rillaerts, K.; Garg, A. D.; Schepkens, C.; Bosisio, F. M.; Wouters, J.; Oliveira, A. I.; Vangheluwe, P.; Annaert, W.; Swinnen, J. V.; Colet, J. M.; van den Oord, J. J.; Fendt, S. -M.; Mazzone, M.; Agostinis, P. | |
| Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice | 1-gen-2010 | Casazza, Andrea; Finisguerra, V; Capparuccia, Lorena; Camperi, Andrea; Swiercz, Jm; Rizzolio, Sabrina; Rolny, C; Christensen, C; Bertotti, Andrea; Sarotto, I; Risio, M; Trusolino, Livio; Weitz, J; Schneider, M; Mazzone, M; Comoglio, Paolo; Tamagnone, Luca | |
| Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer | 1-gen-2022 | Cappellesso, F.; Orban, M. -P.; Shirgaonkar, N.; Berardi, E.; Serneels, J.; Neveu, M. -A.; Di Molfetta, D.; Piccapane, F.; Caroppo, R.; Debellis, L.; Ostyn, T.; Joudiou, N.; Mignion, L.; Richiardone, E.; Jordan, B. F.; Gallez, B.; Corbet, C.; Roskams, T.; Dasgupta, R.; Tejpar, S.; Di Matteo, M.; Taverna, D.; Reshkin, S. J.; Topal, B.; Virga, F.; Mazzone, M. | |
| Role and therapeutic potential of dietary ketone bodies in lymph vessel growth | 1-gen-2019 | Garcia-Caballero, M.; Zecchin, A.; Souffreau, J.; Truong, A. -C. K.; Teuwen, L. -A.; Vermaelen, W.; Martin-Perez, R.; de Zeeuw, P.; Bouche, A.; Vinckier, S.; Cornelissen, I.; Eelen, G.; Ghesquiere, B.; Mazzone, M.; Dewerchin, M.; Carmeliet, P. | |
| N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages | 1-gen-2021 | Menga, A.; Favia, M.; Spera, I.; Vegliante, M. C.; Gissi, R.; De Grassi, A.; Laera, L.; Campanella, A.; Gerbino, A.; Carra, G.; Canton, M.; Loizzi, V.; Pierri, C. L.; Cormio, G.; Mazzone, M.; Castegna, A. | |
| Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness | 1-gen-2021 | Jiang, X.; Hu, J.; Wu, Z.; Cafarello, S. T.; Di Matteo, M.; Shen, Y.; Dong, X.; Adler, H.; Mazzone, M.; Ruiz de Almodovar, C.; Wang, X. | |
| Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity | 1-gen-2017 | Hernandez-Fernaud, J. R.; Ruengeler, E.; Casazza, A.; Neilson, L. J.; Pulleine, E.; Santi, A.; Ismail, S.; Lilla, S.; Dhayade, S.; Macpherson, I. R.; Mcneish, I.; Ennis, D.; Ali, H.; Kugeratski, F. G.; Al Khamici, H.; Van Den Biggelaar, M.; Van Den Berghe, P. V. E.; Cloix, C.; Mcdonald, L.; Millan, D.; Hoyle, A.; Kuchnio, A.; Carmeliet, P.; Valenzuela, S. M.; Blyth, K.; Yin, H.; Mazzone, M.; Norman, J. C.; Zanivan, S. | |
| The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation | 1-gen-2013 | Luca, R.; Averna, M.; Zalfa, F.; Vecchi, M.; Bianchi, F.; Fata, G. L.; Del Nonno, F.; Nardacci, R.; Bianchi, M.; Nuciforo, P.; Munck, S.; Parrella, P.; Moura, R.; Signori, E.; Alston, R.; Kuchnio, A.; Farace, M. G.; Fazio, V. M.; Piacentini, M.; De Strooper, B.; Achsel, T.; Neri, G.; Neven, P.; Evans, D. G.; Carmeliet, P.; Mazzone, M.; Bagni, C. | |
| Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization | 1-gen-2009 | Mazzone, M; Dettori, Daniela; Leite de Oliveira, R; Loges, S; Schmidt, T; Jonckx, B; Tian, Ym; Lanahan, Aa; Pollard, P; Ruiz de Almodovar, C; De Smet, F; Vinckier, S; Aragonés, J; Debackere, K; Luttun, A; Wyns, S; Jordan, B; Pisacane, A; Gallez, B; Lampugnani, Mg; Dejana, E; Simons, M; Ratcliffe, P; Maxwell, P; Carmeliet, P. | |
| Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation | 1-gen-2021 | Virga, F.; Cappellesso, F.; Stijlemans, B.; Henze, A. -T.; Trotta, R.; van Audenaerde, J.; Mirchandani, A. S.; Sanchez-Garcia, M. A.; Vandewalle, J.; Orso, F.; Riera-Domingo, C.; Griffa, A.; Ivan, C.; Smits, E.; Laoui, D.; Martelli, F.; Langouche, L.; van den Berghe, G.; Feron, O.; Ghesquiere, B.; Prenen, H.; Libert, C.; Walmsley, S. R.; Corbet, C.; van Ginderachter, J. A.; Ivan, M.; Taverna, D.; Mazzone, M. | |
| Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis | 1-gen-2018 | Kalucka, J.; Bierhansl, L.; Conchinha, N. V.; Missiaen, R.; Elia, I.; Bruning, U.; Scheinok, S.; Treps, L.; Cantelmo, A. R.; Dubois, C.; de Zeeuw, P.; Goveia, J.; Zecchin, A.; Taverna, F.; Morales-Rodriguez, F.; Brajic, A.; Conradi, L. -C.; Schoors, S.; Harjes, U.; Vriens, K.; Pilz, G. -A.; Chen, R.; Cubbon, R.; Thienpont, B.; Cruys, B.; Wong, B. W.; Ghesquiere, B.; Dewerchin, M.; De Bock, K.; Sagaert, X.; Jessberger, S.; Jones, E. A. V.; Gallez, B.; Lambrechts, D.; Mazzone, M.; Eelen, G.; Li, X.; Fendt, S. -M.; Carmeliet, P. | |
| Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity | 1-gen-2013 | Casazza, Andrea; Laoui, Damya; Wenes, Mathias; Sabrina, Rizzolio; Bassani, Nicklas; Mambretti, Marco; Deschoemaeker, Sofie; Van ginderachter, J. o. . A.; Luca, Tamagnone; Mazzone, Massimiliano | |
| MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis | 1-gen-2016 | Stijlemans, B.; Brys, L.; Korf, H.; Bieniasz-Krzywiec, P.; Sparkes, A.; Vansintjan, L.; Leng, L.; Vanbekbergen, N.; Mazzone, M.; Caljon, G.; Van Den Abbeele, J.; Odongo, S.; De Trez, C.; Magez, S.; Van Ginderachter, J. A.; Beschin, A.; Bucala, R.; De Baetselier, P. | |
| Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism | 1-gen-2017 | Thompson, A. A. R.; Dickinson, R. S.; Murphy, F.; Thomson, J. P.; Marriott, H. M.; Tavares, A.; Willson, J.; Williams, L.; Lewis, A.; Mirchandani, A.; Coelho, P. D. S.; Doherty, C.; Ryan, E.; Watts, E.; Morton, N. M.; Forbes, S.; Stimson, R. H.; Hameed, A. G.; Arnold, N.; Preston, J. A.; Lawrie, A.; Finisguerra, V.; Mazzone, M.; Sadiku, P.; Goveia, J.; Taverna, F.; Carmeliet, P.; Foster, S. J.; Chilvers, E. R.; Cowburn, A. S.; Dockrell, D. H.; Johnson, R. S.; Meehan, R. R.; Whyte, M. K. B.; Walmsley, S. R. | |
| Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population | 1-gen-2014 | Laoui, D.; Van Overmeire, E.; Conza, G. D.; Aldeni, C.; Keirsse, J.; Morias, Y.; Movahedi, K.; Houbracken, I.; Schouppe, E.; Elkrim, Y.; Karroum, O.; Jordan, B.; Carmeliet, P.; Gysemans, C.; Debaetselier, P.; Mazzone, M.; Van Ginderachter, J. A. | |
| Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function | 1-gen-2021 | Duquenne, M.; Folgueira, C.; Bourouh, C.; Millet, M.; Silva, A.; Clasadonte, J.; Imbernon, M.; Fernandois, D.; Martinez-Corral, I.; Kusumakshi, S.; Caron, E.; Rasika, S.; Deliglia, E.; Jouy, N.; Oishi, A.; Mazzone, M.; Trinquet, E.; Tavernier, J.; Kim, Y. -B.; Ory, S.; Jockers, R.; Schwaninger, M.; Boehm, U.; Nogueiras, R.; Annicotte, J. -S.; Gasman, S.; Dam, J.; Prevot, V. | |
| Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis | 1-gen-2012 | Kiss, J.; Mollenhauer, M.; Walmsley, S. R.; Kirchberg, J.; Radhakrishnan, P.; Niemietz, T.; Dudda, J.; Steinert, G.; Whyte, M. K. B.; Carmeliet, P.; Mazzone, M.; Weitz, J.; Schneider, M. | |
| Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity | 1-gen-2012 | Leite de Oliveira, R.; Deschoemaeker, S.; Henze, A. -T.; Debackere, K.; Finisguerra, V.; Takeda, Y.; Roncal, C.; Dettori, D.; Tack, E.; Jonsson, Y.; Veschini, L.; Peeters, A.; Anisimov, A.; Hofmann, M.; Alitalo, K.; Baes, M.; D'Hooge, J.; Carmeliet, P.; Mazzone, M. | |
| Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium | 1-gen-2017 | Reid, S. E.; Kay, E. J.; Neilson, L. J.; Henze, A. -T.; Serneels, J.; Mcghee, E. J.; Dhayade, S.; Nixon, C.; Mackey, J. B. G.; Santi, A.; Swaminathan, K.; Athineos, D.; Papalazarou, V.; Patella, F.; Roman-Fernandez, A.; Elmaghloob, Y.; Hernandez-Fernaud, J. R.; Adams, R. H.; Ismail, S.; Bryant, D. M.; Salmeron-Sanchez, M.; Machesky, L. M.; Carlin, L. M.; Blyth, K.; Mazzone, M.; Zanivan, S. |
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