11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer.

Franzese, C; Lopci, E; Di Brina, L; D'Agostino, Gr; Navarria, P; Mancosu, P; Tomatis, S; Chiti, A; Scorsetti, M

doi:10.1080/07357907.2017.1375116

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Introduction: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.Materials and methods: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.Results: twenty-six patients, 38 lymph node metastases were irradiated. No grade 2 toxicity. Median PSA-nadir after RT was 1.02ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).Conclusion: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

Titolo:	11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer.
Autori:	FRANZESE, Ciro Lopci E Di Brina L D'Agostino GR Navarria P Mancosu P Tomatis S CHITI, ARTURO SCORSETTI, Marta mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2017
Rivista:	CANCER INVESTIGATION
Abstract:	Introduction: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.Materials and methods: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.Results: twenty-six patients, 38 lymph node metastases were irradiated. No grade 2 toxicity. Median PSA-nadir after RT was 1.02ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).Conclusion: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.
Handle:	http://hdl.handle.net/11699/2113
Appare nelle tipologie:	1.1 Articolo in rivista

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