Purpose: To examine the incremental effect of adding 3D-mammography with tomosynthesis to standard 2D digital mammography in population breast screening. Methods and Materials: STORM is a prospective comparative study of integrated 2D/3D and 2D-only mammography that investigated screening in two phases [2D relative to 2D/3D obtained with Combo®], yielding paired data for each screening examination. Women aged ³49 years who attended population-based screening services in Trento and Verona (Italy), from September 2011 to March 2012, were included. Screens were interpreted sequentially using standard double-reading, with recall of a positive screen at either reading phases. Paired proportions were compared using McNemar's Chi-square test. Results: Based on 5000 screens, 33 breast cancers were detected: 23 cancers were detected at both 2D and 2D/3D reading, 10 cancers were detected only with integrated 2D/3D screening, and no cancers were detected only at 2D reading (p=0.002); incremental detection attributable to 2D/3D screening was 2.0/1000 screens (95% CI 0.8-3.2/1000) or an incremental 30.3% (95% CI 15.6-48.7%) of cancers. There were 299 false positive (FP) recalls: 141 were FP at both reading phases, 106 were FP at 2D-only, and 52 were FP at 2D/3D reading (p < 0.001). Had recall been conditional to 2D/3D screen-positivity, FP recalls would have been reduced by 18.1% (95% CI 13.9-22.9%) without missing any of the breast cancers identified to date in the study population. Conclusion: Integrated 2D/3D mammography has the potential to enhance breast screening outcomes by improving cancer detection as well as by reducing FP recalls. Randomised trials of 2D/3D screening versus standard 2D screening are needed. Author Disclosures: N. Houssami: Grant Recipient; Receives research support via National Health and Medical Research Council program grant 633003 to the Screening & Test Evaluation Program. Other; Travel support was provided by Hologic (USA/Italy) for attendance at collaborators/research meetings. D. Bernardi: Equipment Support Recipient; Technologic support for trial from Hologic USA/Italy. Other; Travel support from Hologic to attend collaborators/research meetings. F. Caumo: Equipment Support Recipient; Technologic support for the trial received through Hologic. Other; Travel support to collaborators meetings was received through Hologic. P. Macaskill: Grant Recipient; Receives research support through National Health and Medical Research Council program grant 633003 to STEP. 10:30 - 12:00 Room G
The STORM trial of screening mammography: screening with Tomosynthesis or standard mammography
Bernardi D;
2013-01-01
Abstract
Purpose: To examine the incremental effect of adding 3D-mammography with tomosynthesis to standard 2D digital mammography in population breast screening. Methods and Materials: STORM is a prospective comparative study of integrated 2D/3D and 2D-only mammography that investigated screening in two phases [2D relative to 2D/3D obtained with Combo®], yielding paired data for each screening examination. Women aged ³49 years who attended population-based screening services in Trento and Verona (Italy), from September 2011 to March 2012, were included. Screens were interpreted sequentially using standard double-reading, with recall of a positive screen at either reading phases. Paired proportions were compared using McNemar's Chi-square test. Results: Based on 5000 screens, 33 breast cancers were detected: 23 cancers were detected at both 2D and 2D/3D reading, 10 cancers were detected only with integrated 2D/3D screening, and no cancers were detected only at 2D reading (p=0.002); incremental detection attributable to 2D/3D screening was 2.0/1000 screens (95% CI 0.8-3.2/1000) or an incremental 30.3% (95% CI 15.6-48.7%) of cancers. There were 299 false positive (FP) recalls: 141 were FP at both reading phases, 106 were FP at 2D-only, and 52 were FP at 2D/3D reading (p < 0.001). Had recall been conditional to 2D/3D screen-positivity, FP recalls would have been reduced by 18.1% (95% CI 13.9-22.9%) without missing any of the breast cancers identified to date in the study population. Conclusion: Integrated 2D/3D mammography has the potential to enhance breast screening outcomes by improving cancer detection as well as by reducing FP recalls. Randomised trials of 2D/3D screening versus standard 2D screening are needed. Author Disclosures: N. Houssami: Grant Recipient; Receives research support via National Health and Medical Research Council program grant 633003 to the Screening & Test Evaluation Program. Other; Travel support was provided by Hologic (USA/Italy) for attendance at collaborators/research meetings. D. Bernardi: Equipment Support Recipient; Technologic support for trial from Hologic USA/Italy. Other; Travel support from Hologic to attend collaborators/research meetings. F. Caumo: Equipment Support Recipient; Technologic support for the trial received through Hologic. Other; Travel support to collaborators meetings was received through Hologic. P. Macaskill: Grant Recipient; Receives research support through National Health and Medical Research Council program grant 633003 to STEP. 10:30 - 12:00 Room GI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
